2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. OX2-2303

OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research.

For research use only. We do not sell to patients.

OX2-2303

OX2-2303 Chemical Structure

CAS No. : 1607428-33-0

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OX2-2303 Related Antibodies

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Description

OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research[1].

IC50 & Target[1]

OX2 Receptor

0.1 nM (Ki)

In Vitro

OX2-2303 (compound 1) exhibits no significant off-target activity across a panel of 59 major CNS targets, with exception of low affinity binding to sigma-2 (Ki = 2681 nM) and NR2B receptors (Ki = 9475 nM)[1].
OX2-2303 shows favorable tracer integrity, with no appreciable radiometabolites detected in saline, serum (mouse, rat, nonhuman primate, and human), and liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OX2-2303 Related Antibodies
Molecular Weight

436.50

Formula

C23H21FN4O2S
CAS No.
SMILES

FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OX2-2303 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX2-23031607428-33-0Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOX2RPETCNSInhibitorinhibitorinhibit

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