O-Desmethylmetoprolol

Cat. No.: HY-131630 Purity: 98.66%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

O-Desmethylmetoprolol is the metabolite of Metoprolol (HY-17503) produced by CYP2D6 enzyme metabolism.

For research use only. We do not sell to patients.

O-Desmethylmetoprolol Chemical Structure

CAS No. : 62572-94-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of O-Desmethylmetoprolol:

O-Desmethylmetoprolol-d₅ Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

O-Desmethylmetoprolol is the metabolite of Metoprolol (HY-17503) produced by CYP2D6 enzyme metabolism^[1].

Molecular Weight

253.34

Formula

C₁₄H₂₃NO₃

CAS No.

62572-94-5

Appearance

Solid

Color

White to off-white

SMILES

OCCC1=CC=C(OCC(O)CNC(C)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (394.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9473 mL	19.7363 mL	39.4726 mL
5 mM	0.7895 mL	3.9473 mL	7.8945 mL
10 mM	0.3947 mL	1.9736 mL	3.9473 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (265 KB) SDS (622 KB)

COA (243 KB) HNMR (259 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Bae SH, et al., Simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: Application to the pharmacokinetics of metoprolol associated with CYP2D6 genotypes. J Sep Sci. 2014 Jun;37(11):1256-64. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9473 mL	19.7363 mL	39.4726 mL	98.6816 mL
	5 mM	0.7895 mL	3.9473 mL	7.8945 mL	19.7363 mL
	10 mM	0.3947 mL	1.9736 mL	3.9473 mL	9.8682 mL
	15 mM	0.2632 mL	1.3158 mL	2.6315 mL	6.5788 mL
	20 mM	0.1974 mL	0.9868 mL	1.9736 mL	4.9341 mL
	25 mM	0.1579 mL	0.7895 mL	1.5789 mL	3.9473 mL
	30 mM	0.1316 mL	0.6579 mL	1.3158 mL	3.2894 mL
	40 mM	0.0987 mL	0.4934 mL	0.9868 mL	2.4670 mL
	50 mM	0.0789 mL	0.3947 mL	0.7895 mL	1.9736 mL
	60 mM	0.0658 mL	0.3289 mL	0.6579 mL	1.6447 mL
	80 mM	0.0493 mL	0.2467 mL	0.4934 mL	1.2335 mL
	100 mM	0.0395 mL	0.1974 mL	0.3947 mL	0.9868 mL