O-Benzylhydroxylamine hydrochloride

Name: O-Benzylhydroxylamine hydrochloride
Brand: MedChemExpress
SKU: HY-41915
Rating: 4.5 (1 reviews)

Cat. No.: HY-41915 Purity: 99.92%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

O-Benzylhydroxylamine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

O-Benzylhydroxylamine hydrochloride Chemical Structure

CAS No. : 2687-43-6

Size	Price	Stock	Quantity
100 g		In-stock	Estimated Time of Arrival: December 31
> 100 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

O-Benzylhydroxylamine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

O-Benzylhydroxylamine is a building block. It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

159.62

Formula

C₇H₁₀ClNO

CAS No.

2687-43-6

Appearance

Solid

Color

White to off-white

SMILES

NOCC1=CC=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (626.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2649 mL	31.3244 mL	62.6488 mL
5 mM	1.2530 mL	6.2649 mL	12.5298 mL
10 mM	0.6265 mL	3.1324 mL	6.2649 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (15.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (271 KB) SDS (614 KB)

COA (247 KB) RP-HPLC (243 KB)

Handling Instructions (2659 KB)

References

[1]. Bellettini, et al. A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitors. Tetrahedron Lett.38(2)167-168(1997).

[2]. Asadipour, et al. N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation. Daru.26(2)199-207(2018). [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.2649 mL	31.3244 mL	62.6488 mL	156.6220 mL
	5 mM	1.2530 mL	6.2649 mL	12.5298 mL	31.3244 mL
	10 mM	0.6265 mL	3.1324 mL	6.2649 mL	15.6622 mL
	15 mM	0.4177 mL	2.0883 mL	4.1766 mL	10.4415 mL
	20 mM	0.3132 mL	1.5662 mL	3.1324 mL	7.8311 mL
	25 mM	0.2506 mL	1.2530 mL	2.5060 mL	6.2649 mL
	30 mM	0.2088 mL	1.0441 mL	2.0883 mL	5.2207 mL
	40 mM	0.1566 mL	0.7831 mL	1.5662 mL	3.9155 mL
	50 mM	0.1253 mL	0.6265 mL	1.2530 mL	3.1324 mL
	60 mM	0.1044 mL	0.5221 mL	1.0441 mL	2.6104 mL
	80 mM	0.0783 mL	0.3916 mL	0.7831 mL	1.9578 mL
	100 mM	0.0626 mL	0.3132 mL	0.6265 mL	1.5662 mL