2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Nusinersen

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy.

For research use only. We do not sell to patients.

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)

Nusinersen Chemical Structure

CAS No. : 1258984-36-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Nusinersen:

Nusinersen Related Antibodies

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1 Publications Citing Use of MCE Nusinersen

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Description

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy[1][2][3].

In Vivo

Nusinersen (6.5 mg/kg; ICV; at postnatal day 1) ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SMNΔ7 mice (Smn-/-;SMN2+/+; SMN∆7+/+, male/female), a severe SMA mouse model[3]
Dosage: 6.5 mg/kg
Administration: Intracerebroventricular (ICV) injection; at postnatal day 1
Result: Improved righting reflex latency, preserved αMN number, reduced motor neuron degeneration, and rescued skeletal muscle fiber size and oxidative metabolism.
Increased SMN protein in spinal cord but not in muscle.
Clinical Trial
Molecular Weight

7127.30

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)
SMILES

[Nusinersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.91%

SDS (480 KB)

COA (245 KB) RP-HPLC (279 KB)

Handling Instructions (2659 KB)
References
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Nusinersen Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nusinersen1258984-36-9DNA/RNA SynthesisSMAspinalmuscularatrophySMN2Inhibitorinhibitorinhibit

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