2. Others Antibody-drug Conjugate/ADC Related
  3. Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)
  4. NOTA trihydrochloride

NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.

For research use only. We do not sell to patients.

NOTA trihydrochloride

NOTA trihydrochloride Chemical Structure

CAS No. : 133256-65-2

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NOTA trihydrochloride Related Antibodies

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Description

NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.

IC50 & Target

RDC Bifunctional Chelator

 

In Vivo

NOTA participates in the synthesis of [64Cu]NOTA-pentixather to enables high resolution PET imaging of CXCR4 expressionin in Daudi lymphoma-bearing severe combined immunodeficiency (SCID) mice [3].
NOTA participates in the synthesis of 68Ga-NOTA-RGD for MicroPET/CT imaging of αvβ3 integrin in rat myocardial infarction[4].
NOTA participates in the synthesis of [68Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma[5].
NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

412.69

Formula

C12H24Cl3N3O6
CAS No.
SMILES

O=C(CN1CCN(CCN(CC1)CC(O)=O)CC(O)=O)O.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NOTA trihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA trihydrochloride133256-65-2Biochemical Assay ReagentsRadionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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NOTA trihydrochloride
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