Nitrobenzylthioinosine 5'-monophosphate  (Synonyms: NBMPR-P)

Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126)^[1][2].

499.39

C₁₇H₁₈N₅O₉PS

65199-10-2

O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N(C=N2)C3=C2C(SCC4=CC=C([N+]([O-])=O)C=C4)=NC=N3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Patel DH, et al. Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells. Blood. 2000 Apr 1;95(7):2356-63.  [Content Brief]

  [2]. el Kouni MH, et al. Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6667-70.  [Content Brief]