Nialamide hydrochloride 

Nialamide hydrochloride is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide hydrochloride inhibits MAO and regulates ROS production. Nialamide hydrochloride induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide hydrochloride can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension^{[1][2][3][4][5][6]}.

Nialamide (10 μM) hydrochloride decreases ROS levels in NMDA (HY-17551)- and Kainic acid (HY-N2309)- stimulated rat cerebellar granule cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nialamide (100 mg/kg; s.c.) hydrochloride enhances hypermotility in female NMRI mice^[3].
Nialamide (1-10 mg/kg; i.v.) hydrochloride potentiates Noradrenaline's pressor effect in Reserpine (HY-N0480)-pretreated pithed cats^[4].
Nialamide (100 mg/kg; i.p.) hydrochloride enhances the anticonvulsant effect of Diphenylhydantoin in mice^[5].
Nialamide (200 mg/kg; i.p.) hydrochloride induces increased motor activity, rectal temperature, and elevated brain 5-HT, NA, and dopamine levels in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.80

C₁₆H₁₉ClN₄O₂

1161-03-1

O=C(C1=CC=NC=C1)NNCCC(NCC2=CC=CC=C2)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Boldyrev AA, et al. Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells. Biochem Biophys Res Commun. 1999 Mar 16;256(2):320-4.  [Content Brief]

  [2]. Lee H, et al. Ionizing radiation induced modification of nialamide as an anti inflammatory agent against lipopolysaccharide induced RAW 264.7 and DH82 cells. Exp Ther Med. 2024 Mar 11;27(5):192.  [Content Brief]

  [3]. Buus Lassen J. Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium. Psychopharmacology (Berl). 1989;98(2):257-61.  [Content Brief]

  [4]. DAVEY MJ, et al. The effects of nialamide on adrenergic functions. Br J Pharmacol Chemother. 1963 Feb;20(1):121-34.  [Content Brief]

  [5]. P'AN SY, et al. Anticonvulsant effect of nialamide and diphenylhydantoin. Proc Soc Exp Biol Med. 1961 Dec;108:680-3.  [Content Brief]

  [6]. Modigh K, et al. On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome. Br J Pharmacol. 1972 Sep;46(1):32-45.  [Content Brief]