2. NF-κB Metabolic Enzyme/Protease
  3. NF-κB HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2
  4. NF-κB/HIF-1α-IN-1

NF-κB/HIF-1α-IN-1 (compound 9c) is a potent blocker of the NF-κB activation pathway and demonstrates selective anti-fibrotic activity. NF-κB/HIF-1α-IN-1 shows no significant cytotoxicity in NCI tumor cell lines. In rat models. NF-κB/HIF-1α-IN-1 has been shown to effectively ameliorate liver fibrosis by inhibiting the expression levels of NF-κB and HIF-1α, while simultaneously inducing the activation of Nrf2.

For research use only. We do not sell to patients.

NF-κB/HIF-1α-IN-1 Chemical Structure

NF-κB/HIF-1α-IN-1 Chemical Structure

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NF-κB/HIF-1α-IN-1 Related Antibodies

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HIF-1α HIF

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Description

NF-κB/HIF-1α-IN-1 (compound 9c) is a potent blocker of the NF-κB activation pathway and demonstrates selective anti-fibrotic activity. NF-κB/HIF-1α-IN-1 shows no significant cytotoxicity in NCI tumor cell lines. In rat models. NF-κB/HIF-1α-IN-1 has been shown to effectively ameliorate liver fibrosis by inhibiting the expression levels of NF-κB and HIF-1α, while simultaneously inducing the activation of Nrf2[1].

Molecular Weight

477.52

Formula

C24H27N7O4
SMILES

O=C1C2=C(N=C(NNCCNC(C3=CC=C(OC)C=C3)=O)N2CC4=CC=CC=C4)N(C)C(N1C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NF-κB/HIF-1α-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB/HIF-1α-IN-1NF-κBHIF/HIF Prolyl-HydroxylaseKeap1-Nrf2Nuclear factor-κBNuclear factor-kappaBHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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