2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Reactive Oxygen Species (ROS) Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite
  4. Nerol

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.

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Nerol

Nerol Chemical Structure

CAS No. : 106-25-2

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Solution
10 mM * 1 mL in DMSO In-stock
Liquid
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Based on 1 publication(s) in Google Scholar

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Nerol Related Antibodies

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Description

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity[1][2].

IC50 & Target

Apoptosis; ROS; Antifungal[1][2]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 EC50
11.7 μM
Compound: Nerol
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
In Vitro

Nerol induces apoptosis associated with the generation of ROS and Ca2+ overload in saprotrophic fungus Aspergillus flavus[1].
The antifungal activity of Nerol (NEL) against Candida albicans, a pathogenic fungus, has a minimum inhibitory concentration (MIC) of 4.4μM that causes noteworthy candidacidal activity through an apoptosis-like mechanism[2].
Nerol triggers mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS in Candida albicans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nerol Related Antibodies
Molecular Weight

154.25

Formula

C10H18O
CAS No.
Appearance

Liquid (Density: 0.876 g/cm3)

Color

Colorless to light yellow

SMILES

C/C(C)=C/CC/C(C)=C\CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.97%

SDS (393 KB)

COA (241 KB) GC (177 KB)

Handling Instructions (2659 KB)
References
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Nerol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nerol106-25-2Reactive Oxygen Species (ROS)FungalMitochondrial MetabolismApoptosisEndogenous MetaboliteAntifungalCalciumROSNELmitochondrialdysfunctionInhibitorinhibitorinhibit

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