2. Autophagy
  3. Autophagy
  4. Multi-Leu peptide triacetate

Multi-Leu peptide triacetate  (Synonyms: ML-peptide, Multi-Leucine (ML)-peptide triacetate)

Cat. No.: HY-P10422A
Handling Instructions Technical Support

Multi-Leu peptide (ML-peptide) triacetate is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide triacetate can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide triacetate can be used to study the specific mechanism of PACE4 in the development of prostate cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Multi-Leu peptide triacetate Chemical Structure

Multi-Leu peptide triacetate Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Multi-Leu peptide triacetate:

Multi-Leu peptide triacetate Related Antibodies

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Description

Multi-Leu peptide (ML-peptide) triacetate is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide triacetate can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide triacetate can be used to study the specific mechanism of PACE4 in the development of prostate cancer[1].

Molecular Weight

1231.53

Formula

C55H106N16O15
Appearance

Solid

Sequence

Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
Sequence Shortening

Ac-LLLLRVKR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (40.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8120 mL 4.0600 mL 8.1200 mL
5 mM 0.1624 mL 0.8120 mL 1.6240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8120 mL 4.0600 mL 8.1200 mL 20.3000 mL
5 mM 0.1624 mL 0.8120 mL 1.6240 mL 4.0600 mL
10 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0300 mL
15 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3533 mL
20 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0150 mL
25 mM 0.0325 mL 0.1624 mL 0.3248 mL 0.8120 mL
30 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.6767 mL
40 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5075 mL
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Multi-Leu peptide triacetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-Leu peptide triacetateML-peptide, Multi-Leucine (ML)-peptide triacetateAutophagyInhibitorinhibitorinhibit

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