2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. MEDI4276

MEDI4276 is a HER2-targeting antibody-drug conjugate (ADC). MEDI4276 promotes the internalization of the receptor-antibody complex, precisely delivering the potent cytotoxic drug Tubulysin (HY-128914) into tumor cells, disrupting microtubule dynamics and inducing apoptosis of tumor cells. MEDI4276 is promising for research of HER2-positive tumors.

For research use only. We do not sell to patients.

MEDI4276 Chemical Structure

MEDI4276 Chemical Structure

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MEDI4276 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

MEDI4276 is a HER2-targeting antibody-drug conjugate (ADC). MEDI4276 promotes the internalization of the receptor-antibody complex, precisely delivering the potent cytotoxic drug Tubulysin (HY-128914) into tumor cells, disrupting microtubule dynamics and inducing apoptosis of tumor cells. MEDI4276 is promising for research of HER2-positive tumors[1].

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[MEDI4276]
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MEDI4276 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEDI4276MEDI 4276MEDI-4276Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1HER2ADCtumor cellsInhibitorinhibitorinhibit

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