2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MDL 72527

MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.

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MDL 72527 Chemical Structure

MDL 72527 Chemical Structure

CAS No. : 93565-01-6

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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

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MDL 72527 Related Antibodies

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Description

MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects[1][2].

IC50 & Target

polyamine oxidase (PAO)[1]
In Vitro

MDL 72527 (300 µM; 24 h) shows evident morphological changes with the appearance of a large number of lysosomes and numerous cytoplasmic vacuoles in M14 WT cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDL 72527 Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: M14 cells
Concentration: 300 µM
Incubation Time: 24 h
Result: Showed no significant effect on cell survival of melanoma cells.
In Vivo

MDL 72527 (100 mg/kg; i.p.; once) shows neuroprotective against neuronal cell damage after temporary focal cerebral ischemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-300 g, Male spontaneously hypertensive rats (SHRs)[1]
Dosage: 100 mg/kg
Administration: I.p.; after the induction of ischemia
Result: Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex.
Molecular Weight

265.22

Formula

C12H22Cl2N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=C=CCNCCCCNCC=C=C.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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MDL 72527 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDL 7252793565-01-6MDL72527MDL-72527Monoamine OxidaseMAOInhibitorinhibitorinhibit

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