2. Academic Validation
  3. Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2

Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2

  • Science. 1976 Sep 17;193(4258):1135-7. doi: 10.1126/science.959827.
E F Ellis,  O Oelz,  L J Roberts 2nd,  N A Payne,  B J Sweetman,  A S Nies,  J A Oates
PMID: 959827 DOI: 10.1126/science.959827
Abstract

When human platelets are aggregated by Thrombin, material is released that rapidly contracts strips of spirally cut porcine coronary artery. Prevention of the contraction by indomethacin suggested mediation by a prostaglandin. The contraction produced by aggregating platelets was unlike those produced by prostaglandins E2, F2alpha, G2, or H2, but resembled that evoked by thromboxane A2, which is formed by platelets during aggregation.

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