2. Academic Validation
  3. Effective diameters of ion channels formed by homologs of the antibiotic chrysospermin

Effective diameters of ion channels formed by homologs of the antibiotic chrysospermin

  • Membr Cell Biol. 1997;11(4):497-505.
V I Ternovsky 1,  P A Grigoriev,  G N Berestovsky,  R Schlegel,  K Dornberger,  U Gräfe
Affiliations

Affiliation

  • 1 Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
PMID: 9553937
Abstract

Radii of ion channels formed in the lipid bilayer by 4 homologs of the alamethicin-like Antibiotic, chrysospermin, were determined using hydrophilic nonelectrolytes. It is shown that the replacement of isovaline amino acid at position 15 of the polypeptide chain by alpha-aminoisobutyric acid results in the decrease in the channel effective radius from 1.2 +/- 0.15 to 0.94 +/- 0.1 nm and a respective 2.5-fold decrease in channel conductance.

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