2. Academic Validation
  3. Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp

Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp

  • J Antibiot (Tokyo). 1996 Sep;49(9):839-45. doi: 10.7164/antibiotics.49.839.
Y Murakami 1,  S Kato,  M Nakajima,  M Matsuoka,  H Kawai,  K Shin-Ya,  H Seto
Affiliations

Affiliation

  • 1 Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
PMID: 8931715 DOI: 10.7164/antibiotics.49.839
Abstract

Formobactin, a new free radical scavenger, was isolated from the culture of Nocardia sp. strain ND20. The structure of formobactin was determined to be a member of the nocobactin group Antibiotics. Formobactin inhibited lipid peroxidation in rat brain homogenate. Formobactin also showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.

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