2. Academic Validation
  3. Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

  • J Antibiot (Tokyo). 1994 Feb;47(2):154-62. doi: 10.7164/antibiotics.47.154.
Y K Kim 1,  H Tomoda,  H Nishida,  T Sunazuka,  R Obata,  S Omura
Affiliations

Affiliation

  • 1 Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 8150710 DOI: 10.7164/antibiotics.47.154
Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol Acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

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