2. Academic Validation
  3. [Effect of growth hormone on polynucleotide phosphorylase activity in a primary monolayer culture of rat hepatocytes]

[Effect of growth hormone on polynucleotide phosphorylase activity in a primary monolayer culture of rat hepatocytes]

  • Biull Eksp Biol Med. 1980 Dec;90(12):692-4.
V P Fedotov,  G N Pluzhnikova,  E B Khoroshutina,  E S Ianakopulu,  L E Andrianova
PMID: 7470604
Abstract

Growth hormone (1 microgram/ml) inoculated into the primary culture of rat hepatocytes and incubated for 3 hours at 37 degrees C decreases 2-fold the activity of polynucleotide Phosphorylase (PNPase). In the culture of hepatocytes from hypophysectomized rats, the basal activity of PNPase is significantly higher as compared with that in the culture of hepatocytes from intact Animals. The most pronounced inhibitory effect of growth hormone on PNPase was seen in the culture of hepatocytes from hypophysectomized Animals.

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