2. Academic Validation
  3. gamma-Chloronorvaline, a leucine analog from Streptomyces

gamma-Chloronorvaline, a leucine analog from Streptomyces

  • J Antibiot (Tokyo). 1980 Nov;33(11):1249-55. doi: 10.7164/antibiotics.33.1249.
S Narayanan,  M R Iyengar,  P L Ganju,  S Rengaraju,  T Shomura,  T Tsuruoka,  S Inouye,  T Niida
PMID: 6894746 DOI: 10.7164/antibiotics.33.1249
Abstract

gamma-Chloronorvaline (AL-719) and gamma-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with there respective configurations of (2S, 4S) and (2S, 4R). AL-719 shows Antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.

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