2. Academic Validation
  3. Empedopeptin (BMY-28117), a new depsipeptide antibiotic. I. Production, isolation and properties

Empedopeptin (BMY-28117), a new depsipeptide antibiotic. I. Production, isolation and properties

  • J Antibiot (Tokyo). 1984 Sep;37(9):949-57. doi: 10.7164/antibiotics.37.949.
M Konishi,  K Sugawara,  M Hanada,  K Tomita,  K Tomatsu,  T Miyaki,  H Kawaguchi,  R E Buck,  C More,  V Z Rossomano
PMID: 6501108 DOI: 10.7164/antibiotics.37.949
Abstract

Empedopeptin is a new Antibiotic produced by empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide Antibiotic containing eight amino acid residues and a C14-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.

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