2. Academic Validation
  3. Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2

Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2

  • Ann Hum Genet. 1983 Jan;47(1):9-17. doi: 10.1111/j.1469-1809.1983.tb00965.x.
D M Swallow,  V S Turner,  D A Hopkinson
PMID: 6301357 DOI: 10.1111/j.1469-1809.1983.tb00965.x
Abstract

Two distinct isozymes (UMPH-1 and UMPH-2) which hydrolyse pyrimidine 5'-nucleotides have been identified in mouse, rat and Chinese hamster tissues. One of these, UMPH-1 appears to be specific for pyrimidine 5'-nucleotides, whereas the Other, UMPH-2 has a broader substrate specificity. UMPH-1 and UMPH-2 show differences in their expression in different tissues. The evidence suggests that UMPH-1 and UMPH-2 are coded by distinct structural gene loci, Umph-1 and Umph-2. These isozymes have not been identified in man, and it is suggested that they may have overlapping electrophoretic mobility.

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