2. Academic Validation
  3. Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica

Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica

  • Antimicrob Agents Chemother. 1982 Aug;22(2):342-5. doi: 10.1128/AAC.22.2.342.
F D Gillin,  D S Reiner,  M Suffness
PMID: 6100431 DOI: 10.1128/AAC.22.2.342
Abstract

Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.

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