2. Academic Validation
  3. Tumor exosome-based drug delivery system targeting ferroptosis and apoptosis for glioblastoma therapy

Tumor exosome-based drug delivery system targeting ferroptosis and apoptosis for glioblastoma therapy

  • Colloids Surf B Biointerfaces. 2025 Sep 30:257:115180. doi: 10.1016/j.colsurfb.2025.115180.
Yechang Xu 1,  Tao Peng 2,  Lijun Liang 3,  Yang Ming 4,  Qian Tang 3,  Wenhui Han 5,  Bo Han 6,  Daquan Chen 7,  Yingchao Liu 8
Affiliations

Affiliations

  • 1 Department of Neurosurgery, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; School of Pharmacy, Yantai University, Yantai, China.
  • 2 Department of Neurosurgery, The First People's Hospital of Qinzhou/The tenth Hospital of Guangxi MedicalUniversity, Qinzhou, Guangxi, China.
  • 3 Department of Neurosurgery, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • 4 Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
  • 5 School of Pharmacy, Yantai University, Yantai, China.
  • 6 Department of Pharmacology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Xicheng District, Beijing, China. Electronic address: dyr_860607@126.com.
  • 7 School of Pharmacy, Yantai University, Yantai, China. Electronic address: cdq1981@126.com.
  • 8 Department of Neurosurgery, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Shandong Institute of Brain Science and Brain-inspired Research, Shandong First Medical University, Jinan, China. Electronic address: Yingchaoliu@email.sdu.edu.cn.
PMID: 41072330 DOI: 10.1016/j.colsurfb.2025.115180
Abstract

Temozolomide (TMZ) is a first-line chemotherapy drug to treat glioblastoma (GBM), but still encounters blood-brain barrier (BBB), and chemotherapy resistance. To address these issues, sensible combination therapy of TMZ with Other novel therapeutic techniques is required. Herein, we developed a tumor cell exosome membrane (EM) based drug delivery platform (EMNPs@TMZ) for encapsulating Reactive Oxygen Species (ROS) responsive fucoidan (Fuc) nanoparticles (FNPs). EMNPs@TMZ system can co-deliver TMZ and luteolin (Lut) for the combined targeting Apoptosis and Ferroptosis. Interestingly, Lut can induce Ferroptosis by inhibiting Nrf2 expression, and also inhibit DNA repair through Wnt/β-catenin, promoting TMZ induced cell Apoptosis. More importantly, this nanoparticle drug delivery system has tumor dual-targeting effect, which enhances the inhibitory effect on glioma growth, thereby improving the survival rate of mice models, and has no significant side effects during the treatment process, particularly in the orthotopic patient-derived xenograft (PDX) model. This biomimetic nanoparticle provides a promising strategy for Ferroptosis combination chemotherapy for GBM therapy.

Keywords

Apoptosis; Combination therapy; Exosome membrane; Ferroptosis; Glioblastoma.

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