2. Academic Validation
  3. In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy

In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy

  • Clin Transl Radiat Oncol. 2025 Sep 15:56:101046. doi: 10.1016/j.ctro.2025.101046.
Anna Kirstein 1,  Dan Ionascu 2,  Michael A S Lamba 2,  Bianca M Ruffolo 1,  Katherine J Crail 1,  Anthony E Mascia 1 2,  Mathieu G Sertorio 2,  Benjamin H Hinrichs 3,  Chad Zender 4,  Maria A Lehn 5,  Trisha M Wise-Draper 5,  John P Perentesis 1,  Yi Zheng 1,  Susanne I Wells 1
Affiliations

Affiliations

  • 1 Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • 2 Department of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA.
  • 3 Department of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
  • 4 Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, OH 45219, USA.
  • 5 Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
PMID: 41049395 DOI: 10.1016/j.ctro.2025.101046
Keywords

Head and Neck Squamous Cell Carcinoma (HNSCC); Proton therapy; Radiation; Relative biological effectiveness (RBE); X-ray radiation.

Figures
Products