2. Academic Validation
  3. Erianin induces apoptosis of thyroid cancer cells via TNF signaling pathway

Erianin induces apoptosis of thyroid cancer cells via TNF signaling pathway

  • Eur J Pharmacol. 2025 Nov 5:1006:178167. doi: 10.1016/j.ejphar.2025.178167.
Nailin Gao 1,  Jihua Han 2,  Xiang Sun 3,  Ju Yu 4,  Jiayong Huang 4,  Rengyun Liu 5,  Yan-Lai Tang 6,  Chunlei Nie 7
Affiliations

Affiliations

  • 1 Department of Breast and Thyroid Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • 2 Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
  • 3 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • 4 Department of Breast and Thyroid Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • 5 Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • 6 Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: tangylai@mail.sysu.edu.cn.
  • 7 Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address: chunleinie@hrbmu.edu.cn.
PMID: 40967355 DOI: 10.1016/j.ejphar.2025.178167
Abstract

Thyroid Cancer is the most common endocrine malignancy, with a rising incidence rate over the past three decades. Although most thyroid cancers are indolent, clinical management of advanced thyroid Cancer is still a challenge. Recent studies identified erianin as a potential anti-tumor drug in several Cancer types; however, whether and how erianin against thyroid Cancer remains elusive. In this study we showed that erianin significantly inhibited cell viability and colony formation of thyroid Cancer cells in a genetic mutation -independent manner, and treatment thyroid Cancer cells with erianin induced remarkable G2/M phase cell cycle arrest and Apoptosis. By performing RNA-sequencing, we identified that TNF signaling pathway was activated by erianin in thyroid Cancer cells. Moreover, the cell growth inhibitory effect of erianin was confirmed in a thyroid Cancer xenograft mice model. These data suggest that erianin induces Apoptosis of thyroid Cancer cells by activating the TNF pathway, and the finding of the anti-tumor effect of erianin indicated a new potential therapeutic strategy for advanced thyroid Cancer.

Keywords

Apoptosis; Cell cycle; Erianin; TNF signaling pathway; Thyroid cancer.

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