2. Academic Validation
  3. Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study

Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study

  • Clin Oral Implants Res. 2025 Sep 4. doi: 10.1111/clr.70038.
Natália Dos Santos Sanches 1 2,  Caroline Liberato Marchiolli 1,  Lara Cristina Cunha Cervantes 1 3,  Maria Cristina Ruiz Voms Stein 1,  Sara Alves Berton 1,  Estéfany Lopes Lemes do Prado 1,  Carina Kampleitner 4 5 6,  Francisley Ávila Souza 1,  Roberta Okamoto 7,  Reinhard Gruber 2 5 8,  Idelmo Rangel Garcia Júnior 1
Affiliations

Affiliations

  • 1 Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry Araçatuba, São Paulo, Brazil.
  • 2 Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
  • 3 University of Brazil, São Paulo, Brazil.
  • 4 Karl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
  • 5 Austrian Cluster for Tissue Regeneration, Vienna, Austria.
  • 6 Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation With AUVA, Vienna, Austria.
  • 7 Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry Araçatuba, São Paulo, Brazil.
  • 8 Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
PMID: 40908780 DOI: 10.1111/clr.70038
Abstract

Introduction: Odanacatib (ODN), a Cathepsin K Inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued. Here, we propose ODN as a topical treatment, the coating of dental implants, to achieve an anabolic shift of early osseointegration.

Material and methods: To this aim, we have coated double acid etching titanium implants (SLA) with and without ODN dispersed in a simulated body fluid (SBF). The implants were inserted into the tibia of 72 male Wistar rats and osseointegration was studied on Days 15 and 40. Biomechanical testing, micro-computed microtomography, and histomorphometric analyses were performed.

Results: Biomechanical testing reveals that after 15 days of healing, removal torque increased from 2.5 Ncm (1.5-4.4) to 3.9 Ncm (1.7-7.6) when comparing SBF alone with SBF containing ODN, respectively (p = 0.017). Consistently, micro-computed microtomography indicated that local bone volume increased from 24.4% (13.86-32.45) to 32.8% (19.7-39.4), respectively (p = 0.003). The same was true for presumed bone-to-implant contact, which was 34.38% (27.0-50.0) and 43.33% (31.6-54.2), respectively (p = 0.035). Histomorphometric analyses confirmed that the new bone area per total area increased from 34.78% (18.9-43.7) to 41.10% (23.5-54.0), respectively (p = 0.102). This trend proceeds after 40 days of osseointegration.

Discussion: These findings suggest that topical delivery of a Cathepsin K Inhibitor can support the early osseointegration phase in an ectopic rodent implantation model.

Keywords

biomechanical testing; dental implants; histomorphometry; odanacatib; osseointegration; rat; μCT.

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