2. Academic Validation
  3. Immuno-protective cationic ginsenoside Rb1 vesicles for macrophage-mediated targeted therapy of inflammatory diseases

Immuno-protective cationic ginsenoside Rb1 vesicles for macrophage-mediated targeted therapy of inflammatory diseases

  • Mater Today Bio. 2025 Aug 12:34:102195. doi: 10.1016/j.mtbio.2025.102195.
Jiawen Luo 1 2 3,  Huizhen Fan 3,  Chenying Shu 1,  Yiming Lin 1 2 3,  Hanqing Li 3 4,  Shunv Cai 1,  Xin Li 5,  Yanfei Mao 4,  Min Lu 3,  Pingbo Xu 1
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
  • 2 Postgraduate Training Base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.
  • 3 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • 4 Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
  • 5 Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
PMID: 40893350 DOI: 10.1016/j.mtbio.2025.102195
Abstract

Inflammatory diseases (IDs), characterized by chronic inflammation, are linked to conditions such as Bacterial and viral infections, arthritis, and neurodegenerative disorders. Current treatments offer only temporary relief, highlighting the need for more effective therapies. Ginsenoside Rb1 (Rb1), with potent anti-inflammatory and antioxidant properties, can self-assemble into nanoparticles. To enhance targeted therapy for IDs, this study explores the effects of cationic modifications on Rb1 self-assemblies (GRb1). Among the various modifications, polyethylenimine (PEI) (GRb1@PEI) is the most effective at enhancing GRb1's ability to specifically target macrophages. In a murine model of LPS-induced sepsis-related acute lung injury (ALI), PEI facilitates the delivery of Rb1 to sites of inflammation. There, Rb1 inhibits the TNF-α signaling pathway, which helps normalize inflammatory markers and reduce immune cell recruitment. Additionally, GRb1@PEI serves as a multifunctional carrier for Antibiotics with diverse physicochemical properties, enhancing Bacterial clearance and alleviating inflammation and immune responses in blood infection-associated ALI and Bacterial pneumonia models. Among four cationic polymer-modified GRb1 variants, this study demonstrates that GRb1@PEI is the most efficient multifunctional nanocarrier for targeted anti-inflammatory therapy of inflammatory diseases, providing important guidance for future therapeutic development.

Keywords

Cationic polymer; Cytokine storm; Drug delivery platform; Ginsenoside Rb1; Inflammatory diseases.

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