2. Academic Validation
  3. Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation

Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation

  • Cell Death Dis. 2025 Aug 18;16(1):625. doi: 10.1038/s41419-025-07841-4.
Qiutong Lu # 1,  Zhaopeng Wang # 2,  Shuixian Cao # 1,  Huan Wang 1,  Nianshuang Li 1,  Yi Hu 1,  Wuhui Ding 3,  Wei Zuo 4,  Junbo Hong 5
Affiliations

Affiliations

  • 1 Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, PR China.
  • 2 Department of Gastroenterology, Guixi People's Hospital Guixi, Yingtan, Jiangxi, PR China.
  • 3 Department of Gastroenterology, Guixi People's Hospital Guixi, Yingtan, Jiangxi, PR China. 517330433@qq.com.
  • 4 Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, PR China. zwcdyfy@qq.com.
  • 5 Department of Gastroenterology, Guixi People's Hospital Guixi, Yingtan, Jiangxi, PR China. ndyfy02352@ncu.edu.cn.
  • # Contributed equally.
PMID: 40825934 DOI: 10.1038/s41419-025-07841-4
Abstract

Helicobacter pylori (H. pylori) Infection is a significant cause of gastric diseases, with its pathogenic mechanisms still not fully understood. This study investigates the role of METTL3, an enzyme involved in m6A methylation, in modulating the CXCL1/NF-κB signaling pathway in H. pylori-induced gastritis. Using both bioinformatics analysis of GEO database and experimental approaches including MeRIP, RIP assays, and immunostaining, this research highlights how METTL3 influences CXCL1 expression and NF-κB pathway activation. Results from both in vitro and in vivo models show that METTL3 increases inflammatory responses and Apoptosis in gastric cells. Suppression of METTL3 resulted in decreased inflammation and Apoptosis, suggesting its potential as a therapeutic target in gastritis management.

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