2. Academic Validation
  3. Multifunctional Plasma-Activated Alginate Dressing Potentiates the Moist Healing of Chronic Infected Wounds

Multifunctional Plasma-Activated Alginate Dressing Potentiates the Moist Healing of Chronic Infected Wounds

  • ACS Appl Mater Interfaces. 2025 Aug 27;17(34):48111-48122. doi: 10.1021/acsami.5c12685.
Xianzhen Jin 1,  Juanjie Duan 1,  Qian Wang 1,  Xixi Jing 2,  Tong Wu 2,  Hao Zhang 3 4 5,  Li Guo 2 4 5,  Jishen Zhang 2 4 5,  Wei Zhao 1,  Jianbao Zheng 1,  Xuejun Sun 1,  Dingxin Liu 2 4 5
Affiliations

Affiliations

  • 1 Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 2 State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 3 Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 4 Interdisciplinary Research Center of Frontier Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
  • 5 State Industry-Education Integration Center for Medical Innovations at Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
PMID: 40810284 DOI: 10.1021/acsami.5c12685
Abstract

Although they are beneficial for promoting the moist healing of wounds, alginate dressings often face inherent limitations, such as a lack of Antibacterial and anti-inflammatory activity, in the management of chronic infected wounds. As a green chemical technology for generating reactive oxygen and nitrogen species (RONS), cold atmospheric plasma has shown promise in the bioactivation of medical dressings. Herein, a moist air discharge plasma-activated alginate dressing (mPA-AD) is proposed for enhanced moist healing of chronic infected wounds. In vitro studies reveal that many plasma-generated RONS are effectively loaded into mPA-AD, and mPA-AD exhibits promising RONS storage and slow release properties and is endowed with redox-based Antibacterial and bioregulatory activities. The in vivo results confirm that mPA-AD significantly reduces Bacterial infection, suppresses inflammatory responses, and induces the expression of growth factors, thereby accelerating the healing of chronic infected wounds without significant systemic toxicity. Our findings indicate that mPA-AD could be an effective therapeutic agent for the moist healing of chronic infected wounds.

Keywords

anti-infection; chronic wound; cold atmospheric plasma; plasma-activated alginate dressing; reactive oxygen and nitrogen species.

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