2. Academic Validation
  3. Platelet Membrane Biomimetic Chemiluminescent Nanoparticles for Targeted Therapy of Atherosclerosis

Platelet Membrane Biomimetic Chemiluminescent Nanoparticles for Targeted Therapy of Atherosclerosis

  • ACS Appl Mater Interfaces. 2025 Aug 20;17(33):46680-46692. doi: 10.1021/acsami.5c10093.
Qianru Zhou 1,  Maoqing Huang 1,  Yujie Wang 2,  Dan Mu 1 3 4
Affiliations

Affiliations

  • 1 Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.
  • 2 Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China.
  • 3 Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
  • 4 Yizheng Hospital of Nanjing Drum Tower Hospital Group, Living Area of Sinopec Yizheng Chemical Fibre CO.; LTD., 1 Huannan Road, Yizheng, Jiangsu 211900, China.
PMID: 40785258 DOI: 10.1021/acsami.5c10093
Abstract

Photodynamic therapy (PDT) scavenges diseased cells by using photosensitizers, excitation light, and oxygen. Conventional PDT relies on external excitation light. The depth of penetration of the excitation light is limited, and atherosclerotic plaques are located deep in the tissue, which is not conducive to atherosclerosis treatment. In this study, self-luminescent nanoparticles, platelet membrane (PM)-coated PLGA nanoparticles containing the Photosensitizer chlorin e6 (Ce6) and bis(2,4,5-trichloro-6-[pentyloxycarbonyl]phenyl)oxalate (BTPO) (PM@CBNP), are designed for atherosclerosis therapy. After PM@CBNP targeted the plaque, BTPO reacts with H2O2, exciting Ce6 to generate singlet oxygen (1O2) in the atherosclerotic plaque with overexpressed H2O2. The targeting ability and chemiluminescence of PM@CBNP are investigated in vitro and in vivo. In atherosclerotic mice, PM@CBNP eliminate inflammatory macrophages, reduce the expression of inflammatory factors, and prevent the progression of atherosclerosis. PM@CBNP provide an idea for the therapy of atherosclerosis.

Keywords

atherosclerosis; chemical luminescence; nanoparticles; photodynamic therapy; targeted therapy.

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