2. Academic Validation
  3. Drug functionalized organic electromechanical transistor for rapid and sensitive detection of C-reactive protein

Drug functionalized organic electromechanical transistor for rapid and sensitive detection of C-reactive protein

  • Biosens Bioelectron. 2025 Nov 15:288:117807. doi: 10.1016/j.bios.2025.117807.
Chenyang Li 1,  Chaoyi Yan 1,  Siyu Di 1,  Yu Xiao 2,  Xuefeng Zhang 1,  Ziling Jiang 1,  Guo Liu 1,  Runjie Zhang 1,  Deliu Zeng 1,  Yang Liu 3,  Ye Zou 4,  Jia Li 5,  Fengjiao Zhang 6
Affiliations

Affiliations

  • 1 School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 2 School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; Binzhou Institute of Technology, Binzhou, 256606, Shandong, China.
  • 3 West China Hospital of Sichuan University, Chengdu, 610041, China.
  • 4 Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, China.
  • 5 Department of Orthopedics, Chinese PLA General Hospital, Beijing, 100853, China; National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, 100853, China. Electronic address: lijia@301hospital.com.cn.
  • 6 School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; Binzhou Institute of Technology, Binzhou, 256606, Shandong, China. Electronic address: fjiaozhang@ucas.ac.cn.
PMID: 40712486 DOI: 10.1016/j.bios.2025.117807
Abstract

C-reactive protein (CRP) is a critical biomarker for inflammation and postoperative recovery monitoring. Organic electrochemical transistor (OECT) plays a key role in CRP detection, however, with a limited sensitivity in physiological environment due to inefficient charge transfer within the Debye length. Here, we introduce rosuvastatin (RSV) drug as a novel recognition element for CRP detection in OECT biosensors. The grafted RSV molecules can inherently interact with CRP through electrostatic bonding interaction, contributing to a direct charge transfer between the captured CRP and the device within the Debye length limitation. Following this, the OECT biosensor exhibits a broad range (10-10 to 10-4 g/mL) for CRP quantification, with a short response time of 2 min. Moreover, the devices can realize selective CRP recognition in serum, demonstrating the great potential of drug receptors in electronic biosensor functionalization. This strategy paves a new way for developing ultrasensitive OECT biosensors towards accurate and reliable in-situ biomarker monitoring for convenient disease diagnose.

Keywords

Biosensor; C-reactive protein detection; Organic electrochemical transistor; Rosuvastatin.

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