2. Academic Validation
  3. Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut-Liver Axis Modulation

Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut-Liver Axis Modulation

  • J Agric Food Chem. 2025 Aug 6;73(31):19442-19459. doi: 10.1021/acs.jafc.5c03515.
Minghan Li 1 2 3,  Jialin Guo 1 2 3,  Jinxin Meng 4,  Xueting Wang 1 2 3,  Tianxu Pan 1 2 3,  Dongyu Zhao 1 2 3,  Hongye Li 1 2 3,  Ruyi Gao 1 2 3,  Ya Wang 1 2 3,  Hechun Li 1 2 3,  Songyang Li 1 2 3,  Jiagan Wang 1 2 3,  Haibin Huang 1 2 3,  Nan Wang 1 2 3,  Shuyuan Yu 1 2 3,  Jiayao Guan 1 2 3,  Mingxiao Liu 1 2 3,  Chunfeng Wang 1 2 3,  Guilian Yang 1 2 3
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin 130118, China.
  • 2 Jilin Provincial Engineering Research Center of Animal Probiotics, and Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Jilin Agricultural University, Changchun, Jilin 130118, China.
  • 3 Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, China.
  • 4 Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
PMID: 40708558 DOI: 10.1021/acs.jafc.5c03515
Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by inflammation and immune dysregulation, with the gut-liver axis playing a crucial role in immunometabolic balance. While dietary fibers show therapeutic potential, their mechanisms in T2DM remain unclear. This study investigates the effects of synbiotic intervention combining inulin and Lactiplantibacillus plantarum LPm77 on T2DM, focusing on the gut-liver axis. After 7 weeks of synbiotic treatment, significant improvements in hyperglycemia, Insulin resistance, and hepatic steatosis were observed in T2DM mice. Inulin promoted L. plantarum LPm77 colonization, enhancing the gut microbiota balance and restoring the intestinal barrier function. It also regulated bile acid levels in the enterohepatic circulation. The synbiotic promoted tauro-ursodeoxycholic acid (TUDCA) biosynthesis, improving hepatic lipid metabolism and activating TGR5. TGR5 activation suppressed M1 macrophage polarization via the TGR5-TLR4-NF-κB pathway, reducing pro-inflammatory cytokines and increasing IL-10, thus alleviating systemic inflammation. This study highlights a novel therapeutic approach targeting immune-metabolic dysregulation in T2DM.

Keywords

gut−liver axis; immunometabolic modulation; inulin; synbiotic intervention; tauro-ursodeoxycholic acid (TUDCA); type 2 diabetes mellitus (T2DM).

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