2. Academic Validation
  3. Microbial conversion of daunorubicin into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone

Microbial conversion of daunorubicin into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone

  • J Antibiot (Tokyo). 1985 Sep;38(9):1219-25. doi: 10.7164/antibiotics.38.1219.
K Dornberger,  R Hübener,  W Ihn,  H Thrum,  L Radics
PMID: 4066504 DOI: 10.7164/antibiotics.38.1219
Abstract

By using a strain of Streptomyces willmorii, daunorubicin (daunomycin) was stereoselectively converted into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone. The absolute stereochemistry of the new chiral center in N-acetyl-13(S)-dihydrodaunomycin was established by means of nuclear Overhauser effect measured in the 9,13-O-isopropylidene derivative.

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