2. Academic Validation
  3. Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers

Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers

  • Biomedicines. 2025 Jun 13;13(6):1464. doi: 10.3390/biomedicines13061464.
Radka Boyuklieva 1 2,  Nikolay Zahariev 1 2,  Plamen Simeonov 1,  Dimitar Penkov 1,  Plamen Katsarov 1 2
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
  • 2 Research Institute at Medical University of Plovdiv (RIMU), 4002 Plovdiv, Bulgaria.
PMID: 40564183 DOI: 10.3390/biomedicines13061464
Abstract

Nanotherapeutics have emerged as novel unparalleled drug delivery systems (DDSs) for the treatment of neurodegenerative disorders. By applying different technological approaches, nanoparticles can be engineered to possess different functionalities. In recent years, the developed, stimuli-responsive nanocarriers stand out as novel complex DDSs ensuring selective and specific drug delivery in response to different endogenous and exogenous stimuli. Due to the multifaceted pathophysiology of the nervous system, a major challenge in modern neuropharmacology is the development of effective therapies ensuring high efficacy and low toxicity. Functionalization of the nanocarriers to react to specific microenvironmental changes in the nervous system tissues or external stimulations significantly enhances the efficacy of drug delivery. This review discusses the microenvironmental characteristics of some common neurological diseases in-depth and provides a comprehensive overview on the progress of the development of exogenous and endogenous stimuli-sensitive nanocarriers for the treatment of Alzheimer's and Parkinson's disease.

Keywords

neurodegenerative disorders; stimuli-responsive nanocarriers; targeted delivery.

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