2. Academic Validation
  3. Hafnium hydride Nanosheets with reactive oxygen and nitrogen species and cell-free DNA-dual scavenging capabilities for inflammatory bowel disease treatment

Hafnium hydride Nanosheets with reactive oxygen and nitrogen species and cell-free DNA-dual scavenging capabilities for inflammatory bowel disease treatment

  • J Colloid Interface Sci. 2025 Jun 17;699(Pt 2):138222. doi: 10.1016/j.jcis.2025.138222.
Lulu Liu 1,  Ruoyao Li 1,  Lijuan Xie 1,  Xinxin Zhang 1,  Deyan Gong 1,  Zhengbao Zha 2,  Cheng-Yan Xu 3,  Zhaohua Miao 4
Affiliations

Affiliations

  • 1 School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China.
  • 2 School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China. Electronic address: zbzha@hfut.edu.cn.
  • 3 Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. Electronic address: cy_xu@hit.edu.cn.
  • 4 School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China. Electronic address: zhaohua_miao@hfut.edu.cn.
PMID: 40544617 DOI: 10.1016/j.jcis.2025.138222
Abstract

Inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disease, is closely related to diverse inflammatory factors like reactive oxygen and nitrogen species (RONS) and cell-free DNA (cfDNA). Herein, tannic acid (TA) modified hafnium hydride nanosheets (HfH1.983@TA NSs) with a thickness of 1-4 nm, prepared by liquid-phase exfoliation, were explored as a high-performance anti-inflammatory agent for IBD treatment. By virtue of the high specific surface area of two-dimensional structure, HfH1.983@TA NSs can effectively not only scavenge RONS, but also eliminate cfDNA, thus inhibiting the pro-inflammatory responses. In a dextran sodium sulfate (DSS)-induced IBD mouse model, HfH1.983@TA NSs by oral administration rapidly alleviated various IBD symptoms, including disease activity index (DAI), colon length, and the level of pro-inflammatory cytokines in 5 days, superior to the clinical drug 5-aminosalicylic acid (5-ASA). This work introduces ultrathin hafnium hydride nanosheets with RONS and cfDNA-dual scavenging capabilities as efficient two-dimensional anti-inflammatory agents for IBD treatment.

Keywords

Cell-free DNA; Hafnium hydride nanosheets; Inflammatory bowel disease; ROS scavenging; Two-dimensional materials.

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