2. Academic Validation
  3. Preoperative tyrosine is associated with postoperative delayed neurocognitive recovery in elderly: Evidence from two hospitals

Preoperative tyrosine is associated with postoperative delayed neurocognitive recovery in elderly: Evidence from two hospitals

  • Clin Nutr ESPEN. 2025 Aug:68:727-736. doi: 10.1016/j.clnesp.2025.06.016.
Lei Zhang 1,  Jianhui Liu 2,  Ren Zhou 3,  Jiehui Liu 4,  Jingya Zhang 4,  Haoli Mao 3,  Jia Yan 3,  Hong Jiang 5
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: 72300114040@shsmu.edu.cn.
  • 2 Department of Anesthesiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200000, China. Electronic address: jianhuiliu_1246@163.com.
  • 3 Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
  • 4 Department of Anesthesiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200000, China.
  • 5 Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: jianghongjiuyuan@163.com.
PMID: 40518008 DOI: 10.1016/j.clnesp.2025.06.016
Abstract

Background: Elderly individuals have metabolite alterations that may contribute to delayed neurocognitive recovery (dNCR) following surgery and exposure to anesthesia. Despite its increasing popularity in geriatrics and aging research, dNCR currently lacks specific biomarkers, impeding diagnosis and potential clinical interventions.

Objectives: To determine which metabolites could serve as clinically valuable biomarkers for dNCR.

Methods: Preoperative serum metabolomics were measured in two cohorts: cohort 1 (TJ; N = 43) and cohort 2 (JY; N = 67). dNCR was measured with neuropsychological tests. Differential metabolites were selected from orthogonal partial least-squares discrimination analysis and validated by internal standards. We used logistic regression to examine associations and receiver operating characteristic curves to evaluate predictive ability.

Results: Preoperative serum tyrosine levels were significantly decreased in dNCR compared to non-dNCR groups. Tyrosine levels were associated with dNCR after adjusting for possible confounders in all participants and in subgroup analyses. Areas under the curve were 0.73 in all participants, 0.82 in the TJ cohort, and 0.67 in the JY cohort.

Conclusions: Low preoperative blood tyrosine levels were associated with increased risk of postoperative dNCR in elderly patients. This trial was registered with chictr.org.cn (ChiCTR2200057080) and clinicaltrials.gov (NCT05105451).

Keywords

Anesthesia; Delayed neurocognitive recovery; Metabolomics; Surgery; Tyrosine.

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