Dinuclear Ir(III)-Oligomer as a Sunlight-Driven Hydroxyl Radical Generator for Effective Cancer Photodynamic Therapy

An interesting sunlight-driven photodynamic therapy (PDT) has been realized. In this study, we propose a strategy involving an intramolecular electron-donating ligand to develop a high-performance type-I Photosensitizer. Specifically, an electron-rich core is flanked by two iridium atoms, facilitating electron transfer and promoting hydroxyl radical generation. The resulting Ir(III) Photosensitizer, Q-T, boosts the rapid generation of Reactive Oxygen Species (ROS) under low-intensity laser exposure. Moreover, the type-I ROS ideally suits hypoxic microenvironments, thus demonstrating remarkable PDT against various cell lines, under artificial and natural sunlight. In a skin squamous carcinoma (A431) Organoid model, one cycle of treatment of dosing of Q-T followed by sunlight irradiation effectively induces cellular Apoptosis and completely eradicates tumor organoids. This approach offers a promising avenue for the efficient PDT of skin Cancer utilizing sunlight.

hydroxyl radical; iridium(III) compound; photodynamic therapy; photosensitizer; solid tumor.