2. Academic Validation
  3. Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation

Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation

  • Biomater Adv. 2025 Nov:176:214342. doi: 10.1016/j.bioadv.2025.214342.
Yongman Liu 1,  Yubin Wang 2,  Wenxin Meng 3,  Wenjing Zhang 2,  Shuo Feng 4,  Shangquan Wu 5
Affiliations

Affiliations

  • 1 School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China. Electronic address: liuym@ahmu.edu.cn.
  • 2 School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
  • 3 College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
  • 4 State Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, 230026, China. Electronic address: sfeng18@ustc.edu.cn.
  • 5 CAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, 230026, China; State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Science, Beijing, 100190, China. Electronic address: wushq@ustc.edu.cn.
PMID: 40440989 DOI: 10.1016/j.bioadv.2025.214342
Abstract

Defective bone repair is a pressing issue in the field of bone regeneration due to donor shortages and the associated complications of bone grafting. Artificial bone repair Materials offer more options and are attracting extensive attention from researchers. However, achieving efficient osteogenesis in clinical practice remains a challenge. Here, dual drug-releasing nanofibre membranes (NMs) for bone repair was fabricated by coaxial electrostatic spinning. Strontium-doped hydroxyapatite (SrHA) and desferrioxamine (DFO) were loaded into the shell and core of the NMs for slow and sustained release, respectively. Our results showed that the DFO/SrHA NMs significantly enhanced cell proliferation, angiogenesis and osteogenic differentiation of rat bone mesenchymal stem cells through the synergism of DFO and SrHA. This synergy results from the slow and sustained release of DFO and SrHA via NMs, which maintains the drug concentration in the effective range for a long time, ensuring long-term stable activation of the HIF-1 α and Wnt/β-catenin signalling pathways. Overall, the DFO/SrHA NMs provides a promising strategy for defective bone repair by enhancing osteogenic differentiation.

Keywords

Desferrioxamine; Electrospun nanofiber membrane; Hydroxyapatite; Osteogenic differentiation; Strontium.

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