2. Academic Validation
  3. Stellate ganglion block diminishes consolidation of conditioned fear memory in mice by inhibiting the locus coeruleus to the basolateral amygdala neural circuit

Stellate ganglion block diminishes consolidation of conditioned fear memory in mice by inhibiting the locus coeruleus to the basolateral amygdala neural circuit

  • Transl Psychiatry. 2025 May 17;15(1):172. doi: 10.1038/s41398-025-03383-7.
Ziheng Wang # 1 2 3,  Zhouliang Liu # 3 4 5,  Youjia Yu # 6,  Yuning Sun 1 2 3,  Yan Zhang 1 3,  Kailun Gao 1 3,  Junli Cao 7 8 9,  Liwei Wang 10 11 12,  Yangzi Zhu 13 14 15
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • 2 Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
  • 3 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • 4 Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, Jiangsu, China.
  • 5 NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • 6 Department of Anesthesiology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, China.
  • 7 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China. caojl0310@aliyun.com.
  • 8 Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, Jiangsu, China. caojl0310@aliyun.com.
  • 9 NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, China. caojl0310@aliyun.com.
  • 10 Department of Anesthesiology, Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. doctorlww@sina.com.
  • 11 Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. doctorlww@sina.com.
  • 12 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China. doctorlww@sina.com.
  • 13 Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. zhuyz@xzhmu.edu.cn.
  • 14 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China. zhuyz@xzhmu.edu.cn.
  • 15 NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, China. zhuyz@xzhmu.edu.cn.
  • # Contributed equally.
PMID: 40382311 DOI: 10.1038/s41398-025-03383-7
Abstract

Posttraumatic stress disorder (PTSD) is a devastating, prevalent psychological disorder characterized by excessive fear memory because of exposure to severe trauma. Stellate ganglion block (SGB) is traditionally used as a clinical treatment for pain but has been regarded as an innovative therapy for PTSD in recent reports. However, the mechanisms underlying the effect of SGB on PTSD remain unknown. Here, we established a fear conditioning model, which is considered a representative model of traumatic memory, and evaluated the effect of SGB on conditioned fear memory. We found that SGB reduced conditioned fear memory in mice in conjunction with the hypoactivity of locus coeruleus (LC) noradrenergic and basolateral amygdala (BLA) glutamatergic neurons. The norepinephrine concentration in the BLA decreased after SGB. Moreover, conditioned fear memory was re-enforced when the LC NE (LCNE)-BLA pathway was activated in SGB mice. Our study findings indicated that the hypoactivity of the LCNE-BLA pathway was the potential mechanism underlying the effects of SGB, which diminished consolidation of fear memory to relieve PTSD symptoms.

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