2. Academic Validation
  3. Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers

Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers

  • Fitoterapia. 2025 Jul:184:106627. doi: 10.1016/j.fitote.2025.106627.
Han Wang 1,  Meiling Tai 2,  Wanzhao Li 2,  Yawen Li 1,  Zhimeng Zhang 1,  Dongli Zhang 1,  Lishe Gan 3,  Junhao Li 1,  Xiaojuan Song 4,  Honghong Qiu 1,  Manmei Li 4,  Heyun Zhang 5,  Zhong Liu 6
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • 2 R&D Center, Infinitus (China) Company Ltd, Guangzhou 510405, China.
  • 3 School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
  • 4 School of Pharmacy, Jinan University, Guangzhou 510632, China.
  • 5 Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: zhysums@163.com.
  • 6 Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Key Laboratory of Innovative Technology Research on Natural Products and Cosmetics Raw Materials, Guangzhou 510632, China. Electronic address: tliuzh@jnu.edu.cn.
PMID: 40381851 DOI: 10.1016/j.fitote.2025.106627
Abstract

Mitochondrial dysfunction is one of the important signs of cellular and even individual aging. Ganoderma lucidum is a common edible and medicinal mushroom, widely used as a functional food in Asia. This study investigated the potential Anti-aging effects of Ganoderma lucidum extract (GLE). Our results demonstrated that GLE alleviated cellular oxidative stress, reduced the abnormal increase of mitochondrial ROS in aging cells, and maintained mitochondrial membrane integrity and inner membrane potential. Additionally, GLE affected mitochondrial biogenesis in aging cells. In a murine photoaging model, GLE treatment mitigated UVA-induced mitochondrial dysfunction while markedly attenuating UVA-triggered epidermal thickening and dermal protein depletion. These properties may be interrelated with the presence of abundant triterpenoids identified by LC-MS analysis.

Keywords

Ganoderma lucidum; Mitochondrial dysfunction; Photoaging; UVA.

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