2. Academic Validation
  3. Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus

Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus

  • BMC Microbiol. 2025 May 15;25(1):292. doi: 10.1186/s12866-025-03847-2.
Rongbo Luo # 1,  Beilei Shen # 1,  Bingshuo Qian # 1 2,  Lingjun Fan 1 3,  Junkui Zhang 1 2,  Xiuwen Deng 1 4,  Yan Sun 1 5,  Shijun Zhang 1 4,  Tiecheng Wang 1 6,  Yuanguo Li 1,  Weiyang Sun 1 6,  Xiaobin Pang 7,  Wu Zhong 8,  Yuwei Gao 9 10 11 12 13 14
Affiliations

Affiliations

  • 1 Changchun Veterinary Research Institute, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
  • 2 School of Pharmacy, Henan University, Kaifeng, 475004, China.
  • 3 Engineering Research Center of Glycoconjugates, Ministry of Education, Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun, 130024, China.
  • 4 College of Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China.
  • 5 College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, China.
  • 6 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.
  • 7 School of Pharmacy, Henan University, Kaifeng, 475004, China. pxb@vip.henu.edu.cn.
  • 8 National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. zhongwu@bmi.ac.cn.
  • 9 Changchun Veterinary Research Institute, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Chinese Academy of Agricultural Sciences, Changchun, 130122, China. dawei1105@foxmail.com.
  • 10 School of Pharmacy, Henan University, Kaifeng, 475004, China. dawei1105@foxmail.com.
  • 11 Engineering Research Center of Glycoconjugates, Ministry of Education, Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun, 130024, China. dawei1105@foxmail.com.
  • 12 College of Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. dawei1105@foxmail.com.
  • 13 College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, China. dawei1105@foxmail.com.
  • 14 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China. dawei1105@foxmail.com.
  • # Contributed equally.
PMID: 40375181 DOI: 10.1186/s12866-025-03847-2
Abstract

Background: SARS-CoV-2 and Influenza Virus are highly contagious respiratory viruses that continuously pose major threats to human and public health. The high frequency of viral mutations led to the emergence of resistant isolates and caused virus epidemics repeatedly, emphasizing the urgent need to develop new antivirals. Taurultam is a metabolite of taurolidine. Moreover, taurolidine has been shown to have potent Antiviral activities against multiple viruses and to have Antiviral effects through its metabolites.

Results: In this study, we sought to determine the Antiviral activities of taurultam against SARS-CoV-2 and Influenza Virus in Vero-E6, Huh7, 293T-ACE2, and MDCK cell lines and mouse Infection models. The results showed that taurultam exhibited potent Antiviral activity against multiple SARS-CoV-2 variants, influenza A (H1N1, H3N2) virus and influenza B virus, in vitro. Moreover, in influenza A (H1N1) virus, influenza B virus and SARS-CoV-2 Infection models, taurultam significantly reduced viral loads, increased survival, improved mouse body weight and lung injury. Surprisingly, taurultam treatment not only inhibited the influenza A virus and SARS-CoV-2, but also benefited for therapy of mixed Infection of these two viruses in vitro, demonstrating the great Antiviral potential of taurultam for the treatment of SARS-CoV-2 and Influenza Virus infections.

Conclusions: Together, our findings identify taurultam as a new candidate for the treatment of SARS-CoV-2 and Influenza Virus infections, especially virus-induced lung pathology.

Clinical trial number: Not applicable.

Keywords

Antiviral; Influenza virus; Lung injury; SARS-CoV-2; Taurolidine metabolite; Taurultam.

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