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  3. Research note: Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes

Research note: Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes

  • Poult Sci. 2025 Jul;104(7):105259. doi: 10.1016/j.psj.2025.105259.
Xin Liu 1,  Yixiu Peng 1,  Jun Wu 1,  Hongwu Qian 1,  Xiaoqian Lv 1,  Fan Li 1,  Kai Jin 1,  Yingjie Niu 1,  Jiuzhou Song 2,  Wei Han 3,  Guohong Chen 1,  Bichun Li 4,  Qisheng Zuo 5
Affiliations

Affiliations

  • 1 Key Laboratory of Animal Genetics, Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
  • 2 Animal & Avian Sciences, University of Maryland, College Park, MA 20742, USA. Electronic address: songj88@umd.edu.
  • 3 Poultry Institute, Chinese Academy of Agricultural Sciences Poultry Institute of Jiangsu, Yangzhou 225003, China. Electronic address: hanwei830@163.com.
  • 4 Key Laboratory of Animal Genetics, Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China; College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China. Electronic address: yzu-libichun@163.com.
  • 5 Key Laboratory of Animal Genetics, Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China. Electronic address: 006664@yzu.edu.cn.
PMID: 40359719 DOI: 10.1016/j.psj.2025.105259
Abstract

In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation efficiency and instability of culture systems pose significant challenges, severely limiting the application of PGCs in genetic breeding. In this study, the biological effects of ovotransferrin on chicken PGCs, focusing on its role in regulating key cellular processes. Treatment with 0.5 mg/ml ovotransferrin significantly promoted cell proliferation, enhanced cell adhesion, reduced oxidative stress, and suppressed Apoptosis in cultured PGCs. These findings reveal a regulatory role of ovotransferrin in maintaining PGCs survival and function, providing new insights into optimizing PGC culture systems through targeted modulation of cell fate.

Keywords

Chicken; Primordial germ cell, ovotransferrin, chicken serum.

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