2. Academic Validation
  3. Eremophilane sesquiterpenes from agarwood of Aquilaria agallocha with neuroprotective effect

Eremophilane sesquiterpenes from agarwood of Aquilaria agallocha with neuroprotective effect

  • Phytochemistry. 2025 Sep:237:114527. doi: 10.1016/j.phytochem.2025.114527.
Yanqiao Xie 1,  Siyu Zhang 1,  Tianqi Chen 1,  Chunge Li 2,  Ruonan Tong 1,  Hong Xu 1,  Yingbo Yang 3,  Zhuzhen Han 4,  Zhengtao Wang 5,  Li Yang 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
  • 2 School of Life Science, Zhengzhou Normal University, Henan Province, Zhengzhou, 450044, China.
  • 3 State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Shanghai Tufeng Pharmaceutical Technology Co., Ltd., Shanghai, 201203, China.
  • 4 State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: hltang@126.com.
  • 5 State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: ztwang@shutcm.edu.cn.
  • 6 State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: yl7@shutcm.edu.cn.
PMID: 40306531 DOI: 10.1016/j.phytochem.2025.114527
Abstract

A total of 12 previously undescribed eremophilane-type Sesquiterpenes agalleremonols A-L (1-12) were isolated from the agarwood of Aquilaria agallocha Roxb., and their structures were established based on extensive spectroscopic analyses. The absolute configurations of 1, 4, 5, and 12 were confirmed using single-crystal X-ray analysis, and the Others were determined through electronic circular dichroism (ECD) calculations. The protective activity of the isolated compounds against corticosterone (CORT)-induced damage in PC12 cells was assayed, and 2, 4, and 11 exhibited definite neuroprotective effects with survival rates of 82.14 %, 72.63 %, and 74.36 %, respectively. Flow cytometry and western blotting analyses indicated that the neuroprotective effect of 2 might be attributed to the alleviation of CORT-induced mitochondrial-dependent Apoptosis.

Keywords

Aquilaria agallocha Roxb.; Eremophilane-type sesquiterpenes; Neuroprotective effect; Thymelaeaceae.

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