2. Academic Validation
  3. The Elevation and Impact of Peripheral Bile Acids in Chronic Lymphocytic Leukemia

The Elevation and Impact of Peripheral Bile Acids in Chronic Lymphocytic Leukemia

  • Biomedicines. 2025 Apr 4;13(4):874. doi: 10.3390/biomedicines13040874.
Audrey L Smith 1,  Abigail Ridout 1,  Sydney A Skupa 1,  Rolando Martinez-Rico 1,  Erin M Drengler 1,  Eslam Mohamed 2,  Christopher R D'Angelo 3 4,  Dalia El-Gamal 5
Affiliations

Affiliations

  • 1 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • 2 College of Medicine and College of Graduate Studies, California Northstate University, Elk Grove, CA 95757, USA.
  • 3 Division of Hematology and Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • 4 Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • 5 Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
PMID: 40299495 DOI: 10.3390/biomedicines13040874
Abstract

Background: Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the Western world. Targeted therapies have made CLL manageable for many patients, but the ongoing threat of disease relapse or transformation beckons a deeper understanding of CLL pathogenesis, and thus, its durable eradication. This study identifies bile acids (BAs) as elevated in the peripheral blood of CLL patients and a murine model of CLL, in comparison to healthy controls. Elevated BA concentrations have been associated with intestinal malignancies and immunomodulation; however, their role in CLL is relatively unknown. Methods: Metabolomic analysis was performed on murine and human plasma. Flow cytometry analysis of CLL patient B-cells and healthy donor T-cells were utilized to evaluate the immunomodulatory impact of differentially abundant BAs. Results: Herein, BAs were found to be differentially abundant in CLL. Elevated BAs demonstrated minimal impact on CLL cell proliferation or CLL-associated T-cell function. Conclusions: Future studies are needed to determine the mechanistic influence of BAs on CLL pathogenesis.

Keywords

TCL1 mouse model; bile acids; chronic lymphocytic leukemia (CLL); metabolomics.

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