2. Academic Validation
  3. IL-10 alleviates aTCMR by inhibiting NFATc1 signaling pathway of T cells after kidney transplantation

IL-10 alleviates aTCMR by inhibiting NFATc1 signaling pathway of T cells after kidney transplantation

  • Biochim Biophys Acta Mol Basis Dis. 2025 Aug;1871(6):167857. doi: 10.1016/j.bbadis.2025.167857.
Sheng-Li Liu 1,  Peng Zhao 1,  Yan-Man Zhou 2,  Zhi-Guo Peng 1,  Ning Guo 1,  Huai-Bin Sun 3,  Xian-Quan Cui 4
Affiliations

Affiliations

  • 1 Department of organ transplantation, Qilu Hospital of Shandong University, No.107, Wenhua West Road, Jinan 250012, Shandong, China.
  • 2 Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University. No.324, Jingwu Weiqi Road, Jinan 250021, Shandong, China.
  • 3 Department of organ transplantation, Qilu Hospital of Shandong University, No.107, Wenhua West Road, Jinan 250012, Shandong, China. Electronic address: sunhuaibin@email.sdu.edu.cn.
  • 4 Department of organ transplantation, Qilu Hospital of Shandong University, No.107, Wenhua West Road, Jinan 250012, Shandong, China. Electronic address: cuixianquanqlyy@163.com.
PMID: 40268206 DOI: 10.1016/j.bbadis.2025.167857
Abstract

The cause of acute T cell-mediated rejection (aTCMR) is believed to be immune hyperfunction of T cells after kidney transplantation. Nowadays, Calcineurin inhibitors are widely used to inhibit the proliferation of T cells when aTCMR occurs. However, the therapeutic dose window of these drugs is relatively narrow and long time use of these drugs may lead to serious side effects. Besides, whether IL-10, a new immune tolerance mediator, playing a therapeutic role on aTCMR remains unclear. The level of IL-10 decreased in patients with aTCMR, suggesting that IL-10 may be involved in the progression of aTCMR. IL-10 could inhibit the proliferation and metabolism of T cells in vitro and in vivo, accompanied by reducing the levels of IL-2, IFN-γ, and TNF-α. Moreover, we confirmed that IL-10 exerts immunosuppressive effects by inhibiting the NFATc1 signaling pathway of T cells. This viewpoint may provide a new therapeutic idea for clinical application.

Keywords

IL-10; Kidney transplantation; NFATc1 signaling pathway; T cell; aTCMR.

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