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  3. Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury

Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury

  • Acta Pharm. 2025 Apr 10;75(1):103-118. doi: 10.2478/acph-2025-0006.
Liang Xiao 1,  Chengyu Huang 2,  Shanghua Xiao 2,  Lingfeng Xie 2,  Xueyan Zhang 2,  Fucheng Xiao 3,  Huajia Cai 4,  Shuibo Yang 5,  Shengqing Wu 2,  Shoukang Qu 2,  Jia Liu 2 5
Affiliations

Affiliations

  • 1 1Department of Surgery and Oncology, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China.
  • 2 2Shenzhen Zhongjia Biomedical Technology Co., Ltd. Shenzhen, Guangdong 518107, China.
  • 3 3The Center of Campus, Shenzhen Senior High School Group, Shenzhen, Guangdong 518040, China.
  • 4 4Psychiatric Medicine Sophomore, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • 5 5School of Agriculture and Biotechnology Shenzhen Campus of Sun Yat-sen University Shenzhen, Guangdong 518107, China.
PMID: 40208785 DOI: 10.2478/acph-2025-0006
Abstract

Acute kidney injury (AKI) is a growing global health issue with no effective treatments. This study evaluates the therapeutic effects of umbilical cord mesenchymal stem cells (UC-MSCs) on AKI caused by ischemia-reperfusion injury (IRI) in mice. Thirty mice were divided into a sham group, an IRI group, and an MSC-treated group. Renal function was assessed, and histological analysis, immunofluorescence, and Real-Time PCR were used to evaluate renal damage, inflammatory cell presence, and cytokine expression (TNF-α, IL-6, IL-10). Results showed that MSC treatment reduced renal damage, decreased pro-inflammatory cytokines (TNF-α, IL-6), increased anti-inflammatory IL-10, and promoted kidney repair by homing to injury sites. Thus, umbilical cord MSCs may mitigate AKI by reducing inflammation and enhancing renal repair.

Keywords

acute kidney injury; inflammation; renal ischemia-reperfusion; umbilical cord mesenchymal stem cells.

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