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  3. Multifunctional Nanoplatform Based on Gelatin Nanoparticles with Immunomodulatory Capabilities for Combined Immunotherapy and Chemotherapy of Melanoma

Multifunctional Nanoplatform Based on Gelatin Nanoparticles with Immunomodulatory Capabilities for Combined Immunotherapy and Chemotherapy of Melanoma

  • Biomacromolecules. 2025 May 12;26(5):2996-3010. doi: 10.1021/acs.biomac.5c00098.
Ying Chen 1 2,  Miaomiao Zhang 3,  Zongjia Li 1 2,  Jinyao Zheng 1 2,  Yuanhao Zhang 1 2,  Qianyu Guo 1 2,  Suzhen Liu 4,  Yu Chen 1 2,  Wei Wei 5,  Xiue Jiang 1 2,  Jilin Tang 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China.
  • 2 School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P.R. China.
  • 3 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, P. R. China.
  • 4 Department of Cardiology, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun 130041, PR China.
  • 5 Hospital of Stomatology, Jilin University, Changchun 130021, China.
PMID: 40207885 DOI: 10.1021/acs.biomac.5c00098
Abstract

Tumor immunotherapy has shown considerable therapeutic potential, especially when combined with chemotherapy. In this study, we developed a multifunctional nanoplatform GNPs-DOX/R848 that combined immunotherapy and chemotherapy for the treatment of melanoma, in which gelatin nanoparticles (GNPs) were loaded with the immunomodulatory agent resiquimod (R848) and the chemotherapy drug doxorubicin (DOX). GNPs possessed inherent immunomodulatory properties; when combined with R848, they induced a more pronounced polarization of M1-like macrophages by activating the NF-κB signaling pathway, thereby reversing the immunosuppressive tumor microenvironment. Meanwhile, GNPs effectively delivered R848 and DOX to tumor cells, promoting stronger therapeutic effects of the drugs, which strongly induced the immunogenic cell death triggered by DOX, leading to the infiltration of T cells into the tumor tissue. The treatment of melanoma demonstrated that GNPs-DOX/R848 significantly reduced tumor volume, enhanced the therapeutic effects of chemotherapy, providing a new approach for the combined treatment of Cancer with immunotherapy and chemotherapy.

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