2. Academic Validation
  3. Novel Design of Pyrazolyl-Containing Monoterpene Compounds to Enhance Antifungal Efficacy Against Rhizoctonia solani

Novel Design of Pyrazolyl-Containing Monoterpene Compounds to Enhance Antifungal Efficacy Against Rhizoctonia solani

  • J Agric Food Chem. 2025 Mar 26;73(12):7074-7086. doi: 10.1021/acs.jafc.4c10405.
Haowen Huang 1,  Cong Huang 1,  Qingwen Fang 1,  Yuhan Wu 1,  Yuhuan Kuang 1,  Ji Zhang 1,  Guorong Fan 1,  Zongde Wang 1,  Shangxing Chen 1,  Dayong Peng 2
Affiliations

Affiliations

  • 1 College of Forestry, East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species, Jiangxi Agricultural University, Nanchang 330045, China.
  • 2 College of Chemistry and Materials, Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species, Jiangxi Agricultural University, Nanchang 330045, China.
PMID: 40091823 DOI: 10.1021/acs.jafc.4c10405
Abstract

In the fields of agriculture and forestry, there are major unknown risks associated with the toxicity of chemical pesticide residues and pathogen resistance. To address this issue, in this study, 52 novel pyrazole monoterpene compounds were obtained by organic synthesis of highly active monoterpene natural products and evaluated for their in vitro and in vivo Antifungal activities and crystal structure analysis of compound 5b. The results showed that compounds 4g and 8f exhibited remarkable Antifungal activities against Rhizoctonia solani, with the corresponding EC50 values reaching 4.27 and 4.81 mg/L. At the same time, the results of in vivo and in vitro experiments showed that both compounds 4g and 8f had good control effects against rice sheath blight. The Antifungal activity of these compounds was preliminarily explored by scanning electron microscopy, molecular docking, enzyme activity determination, and cytotoxicity, indicating that these compounds have the potential for development into low-toxic Antifungal drugs.

Keywords

Rhizoctonia solani; antifungal activity; monoterpene; natural products; rice sheath blight.

Figures
Products