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  3. Biochemistry and Diseases Related to the Interconversion of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine

Biochemistry and Diseases Related to the Interconversion of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine

  • Int J Mol Sci. 2024 Oct 6;25(19):10745. doi: 10.3390/ijms251910745.
Jan Korbecki 1 2,  Mateusz Bosiacki 2,  Patrycja Kupnicka 2,  Katarzyna Barczak 3,  Paweł Ziętek 4,  Dariusz Chlubek 2,  Irena Baranowska-Bosiacka 2
Affiliations

Affiliations

  • 1 Department of Anatomy and Histology, Collegium Medicum, University of Zielona Góra, Zyty 28, 65-046 Zielona Góra, Poland.
  • 2 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
  • 3 Department of Conservative Dentistry and Endodontics, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
  • 4 Department of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
PMID: 39409074 DOI: 10.3390/ijms251910745
Abstract

Phospholipids are crucial structural components of cells. Phosphatidylcholine and phosphatidylethanolamine (both synthesized via the Kennedy pathway) and phosphatidylserine undergo interconversion. The dysregulation of this process is implicated in various diseases. This paper discusses the role of Enzymes involved in the interconversion of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, specifically phosphatidylethanolamine N-methyltransferase (PEMT), phosphatidylserine synthases (PTDSS1 and PTDSS2), and phosphatidylserine decarboxylase (PISD), with a focus on their biochemical properties. Additionally, we describe the effects of the deregulation of these Enzymes and their roles in both oncological and non-oncological diseases, including nonalcoholic fatty liver disease (NAFLD), Alzheimer's disease, obesity, Insulin resistance, and type II diabetes. Current knowledge on inhibitors of these Enzymes as potential therapeutic agents is also reviewed, although in most cases, inhibitors are yet to be developed. The final section of this article presents a bioinformatic analysis using the GEPIA portal to explore the significance of these Enzymes in Cancer processes.

Keywords

phosphatidylcholine; phosphatidylethanolamine N-methyltransferase; phosphatidylserine decarboxylase; phospholipid.

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