2. Academic Validation
  3. Abierixin, a new polyether antibiotic. Production, structural determination and biological activities

Abierixin, a new polyether antibiotic. Production, structural determination and biological activities

  • J Antibiot (Tokyo). 1985 Dec;38(12):1655-63. doi: 10.7164/antibiotics.38.1655.
L David,  H Leal Ayala,  J C Tabet
PMID: 3841534 DOI: 10.7164/antibiotics.38.1655
Abstract

A new polyether Antibiotic, abierixin, was found in the mycelium of a culture broth of nigericin-producing Streptomyces albus NRRL B-1865. Abierixin was extracted with organic Solvents and purified by column chromatography and HPLC. The structure of abierixin was determined by FAB/MS/MS and CI/MS/MS and 1H and 13C NMR spectrometries. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Nigericin biosynthesis from abierixin is discussed.

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