2. Academic Validation
  3. Polyacetylene Derivatives from the Polypore Fungus (Fistulina hepatica, Agaricomycetes) and Their Antimicrobial Activity

Polyacetylene Derivatives from the Polypore Fungus (Fistulina hepatica, Agaricomycetes) and Their Antimicrobial Activity

  • Int J Med Mushrooms. 2023;25(12):43-53. doi: 10.1615/IntJMedMushrooms.2023050525.
Anastasiia O Whaley 1,  Andrei K Whaley 2,  Anastasia A Orlova 3,  Sergey V Volobuev 4,  Natalia V Shakhova 5,  Sergey N Smirnov 6,  Natalia V Pustovit 7,  Liudmila A Kraeva 8
Affiliations

Affiliations

  • 1 Department of Pharmacognosy, Laboratory of Cellular Mechanisms of Blood Homeostasis, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russian Federation; Laboratory Cellular Mechanisms of Blood Homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russian Federation.
  • 2 Department of Pharmacognosy, Laboratory of Cellular Mechanisms of Blood Homeostasis, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russian Federation.
  • 3 K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation.
  • 4 Laboratory of Systematics and Geography of the Fungi of the Komarov Botanical Institute of the Russian Academy of Sciences, St. Petersburg, Russia.
  • 5 Laboratory of Fungal Biochemistry, Komarov Botanical Institute, Russian Academy of Sciences, Saint Petersburg, Russian Federation.
  • 6 Magnetic Resonance Research Centre of the Research Park, Saint Petersburg State University, Saint Petersburg, Russian Federation.
  • 7 Department of Molecular Biotechnology, Saint Petersburg State Institute of Technology, Saint Petersburg, Russian Federation.
  • 8 Laboratory of Medicinal Bacteriology, Saint Petersburg Pasteur Institute, Saint Petersburg, Russian Federation.
PMID: 37947063 DOI: 10.1615/IntJMedMushrooms.2023050525
Abstract

Chemical investigation of the polypore fungus Fistulina hepatica resulted in the isolation of five compounds, including four new polyacetylenic fatty acid derivatives - isocinnatriacetin B (1), isocinnatriacetin A (2), cinna-triacetin C (3) and ethylcinnatriacetin A (4) together with one known polyacetylene fatty acid derivative - cinnatriacetin A (5). The structures were elucidated using spectroscopic methods (UV, NMR, HR-ESIMS) along with comparison to literature data. Antibacterial activity screening of compounds 1-5 against ESKAPE Bacterial strains in vitro with zones of inhibition (ZOI) was performed and MIC values were established for the most active compounds (3 and 4). Together with that morphological and growth parameters under solid-phase cultivation were also researched.

Figures
Products